Immunogenicity of induced pluripotent stem cell-derived smooth muscle cells results from a reduction in the expression of indoleamine 2,3 dioxygenase (IDO-1)
These results indicate that iPSC-SMC's impaired ability to modulate the immune response through IDO-1 expression contributes to their differing immunogenicity to v-SMC and highlights the importance of immune phenotyping for therapeutic applications of iPSC-derivatives.
Authors
- Melanie Moore (ORCID: https://orcid.org/0000-0001-9676-6868)
- Jordan S. Pober (ORCID: https://orcid.org/0000-0001-5990-1071)
- Vera J. Mehler
- Katherine Partridge
- Chris J Burns
Institutions
- Yale University (US)
Publication Details
- Journal
- Regenerative Medicine
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1080/17460751.2026.2631599
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00