Prognostic Utility of the HFpEF-ABA Score for HFpEF Patients

Our study demonstrates substantial regional heterogeneity in the prognostic utility of the HFpEF-ABA score among patients with HFpEF enrolled in the TOPCAT trial. The score exhibited strong associations with adverse outcomes in the Russia/Georgia cohort, whereas its prognostic discrimination was attenuated in the Americas cohort. (Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function [TOPCAT]; NCT00094302).

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Publication Details

Journal
JACC Advances
Published
2026-02-25
DOI
https://doi.org/10.1016/j.jacadv.2026.102632
Primary Topic
Atrial Fibrillation Management and Outcomes
Type
article
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article

Prognostic Utility of the HFpEF-ABA Score for HFpEF Patients

Wengen Zhu, Xi Chen, Min Ye, Linjuan Guo
JACC Advances
Atrial Fibrillation Management and Outcomes
article

Prognostic Utility of the HFpEF-ABA Score for HFpEF Patients

Wengen Zhu, Xi Chen, Min Ye, Linjuan Guo
article en

Abstract

Our study demonstrates substantial regional heterogeneity in the prognostic utility of the HFpEF-ABA score among patients with HFpEF enrolled in the TOPCAT trial. The score exhibited strong associations with adverse outcomes in the Russia/Georgia cohort, whereas its prognostic discrimination was attenuated in the Americas cohort. (Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function [TOPCAT]; NCT00094302).

JACC AdvancesVol. 5(3)
Fujian Medical University (CN), Sun Yat-sen University (CN), First Affiliated Hospital of Jiangxi Medical College (CN), Jiangxi Provincial People's Hospital (CN), First Affiliated Hospital of Fujian Medical University (CN), The First Affiliated Hospital, Sun Yat-sen University (CN), Sanming University (CN)
Openalex Percentile: Top 48%
Atrial Fibrillation Management and Outcomes
DOIOpen Access PDFOpenAlex
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Prognostic Utility of the HFpEF-ABA Score for HFpEF Patients — Wengen Zhu, Xi Chen, et al. · JACC Advances (2026) | TGRS Research Map | TGRS