Brain and Blood Biomarkers of Major Depressive Disorder

While the individual dysregulated genes are highly variable across studies and brain regions, converging pathways and hub gene functions, including those related to neurodevelopment, mitochondria, neuroinflammation, apoptosis, and transcriptional regulation emerge across studies. Cell-type specific multiomic studies involving understudied brain regions are needed to better understand the pathophysiology of MDD and identify relevant biomarkers and treatment targets.