Colorectal neoplasia rates in Li Fraumeni Syndrome
LFS patients have comparable ADR and higher SDR to average risk adults despite earlier, more frequent surveillance, irrespective of TP53 PGV subtype. Our data support current recommendations for earlier and more frequent colonoscopy surveillance than average-risk guidelines, across LFS phenotypes.
Authors
- Nicolas U. Edgar
- Luke Devon Maese (ORCID: https://orcid.org/0000-0002-8739-9100)
- Madeline Good (ORCID: https://orcid.org/0009-0002-8078-808X)
- Jennie Vagher (ORCID: https://orcid.org/0009-0004-5818-6589)
- Sophia Spiegel (ORCID: https://orcid.org/0009-0008-9116-7506)
- Anh N. Le (ORCID: https://orcid.org/0000-0002-5360-0486)
- Sara Feola (ORCID: https://orcid.org/0000-0002-4012-4310)
- Suzanne P. MacFarland (ORCID: https://orcid.org/0000-0001-5894-6403)
- Casey J. Mehrhoff (ORCID: https://orcid.org/0009-0000-1097-2776)
- Kara N. Maxwell
- Caitlin Orr
- Nathaniel Frucht
- Isabel Anez
- Bryson W. Katona
- Jo Lyman
- J. E. Garber
- Asaf Maoz
- Sophie R. Cahill
- Anne Naumer
Institutions
- Children's Hospital of Philadelphia (US)
- University of Utah (US)
- Huntsman Cancer Institute (US)
- Dana-Farber Cancer Institute (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- The American Journal of Gastroenterology
- Published
- 2026-02-25
- DOI
- https://doi.org/10.14309/ajg.0000000000003976
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00