Targeting ER stress in adrenocortical carcinoma: Celastrol as a novel therapeutic candidate
identifying agents capable of complementing or replacing standard therapy remains a central challenge in ACC research. Our findings suggest that celastrol is a potent bioactive compound with activity against both monolayer and 3D ACC models, offering potential translational relevance. By elucidating ER stress as a shared mechanism between celastrol and mitotane, our work supports further exploration of this pathway as a strategy to potentially improve therapeutic outcomes in ACC patients.
Authors
- Paola Perotti
- Aurora Schiavon
- Ymera Pignochino (ORCID: https://orcid.org/0000-0001-5073-8618)
- Soraya Puglisi (ORCID: https://orcid.org/0000-0002-2883-6139)
- Marco Lo Iacono (ORCID: https://orcid.org/0000-0002-3936-4472)
- Jessica Petiti (ORCID: https://orcid.org/0000-0001-8640-2462)
- Carlotta Evaristo
- Erika Messina
- Claudia Giachino
- Laura Saba
- Massimo Terzolo
Institutions
- Istituto Nazionale di Ricerca Metrologica (IT)
- Candiolo Cancer Institute (IT)
- Department of Public Health (US)
- University of Turin (IT)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1016/j.biopha.2026.119156
- Primary Topic
- Natural Compounds in Disease Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00