The exosomal miR-26b-3p derived from Crohn’s disease-associated mesenteric adipose tissue induces M1 macrophage polarization and exacerbates ileocolonic anastomosis inflammation via the p38-MAPK signaling pathway
Our findings reveal that exosomal miR-26b-3p drives widespread macrophage inflammation and M1 polarization in hypertrophic MAT-induced ileocolonic anastomosis inflammation via the MAPK pathway.
Authors
- Zhen Guo (ORCID: https://orcid.org/0000-0001-6288-9894)
- Zeqian Yu
- X L Zhang
- Enhao Wu
- Lili Gu (ORCID: https://orcid.org/0000-0003-3844-3563)
- Wenwei Qian (ORCID: https://orcid.org/0000-0002-0979-7568)
- Weiming Zhu
- Yi Li
Institutions
- Soochow University (TW)
- Nanjing General Hospital of Nanjing Military Command (CN)
- Nanjing Maternity and Child Health Care Hospital (CN)
- Affiliated Hospital of Jining Medical University (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-25
- DOI
- https://doi.org/10.3389/fimmu.2026.1754302
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00