Fluorescence-guided surgery combined with intraoperative photodynamic therapy for recurrent atypical and anaplastic intracranial meningiomas: a prospective feasibility study
The integrated FGS and PDT protocol is feasible, safe, and demonstrates compelling preliminary efficacy for recurrent atypical and anaplastic meningiomas. It enhances resection and induces profound cytotoxic and apoptotic effects in the residual tumor bed and peritumoral zone. These results need to be further validated in larger, randomized controlled trials.
Authors
- Maxim Alekseevich Shevtsov (ORCID: https://orcid.org/0000-0002-8539-2239)
- V. V. Ushanov (ORCID: https://orcid.org/0000-0002-4091-7396)
- K. K. Kukanov (ORCID: https://orcid.org/0000-0002-1123-8271)
- A Nechaeva
- Danila Bobkov (ORCID: https://orcid.org/0000-0002-0358-9266)
- Alexey Yurievich Ulitin
- Daria Sitovskaya
- Victor E. Olyushin
- Konstantin Samochernykh
- Stephanie E. Combs
Institutions
- TUM Klinikum (DE)
- Institute of Cytology (RU)
- Russian Scientific Research Neurosurgical Institute (RU)
- Technical University of Munich (DE)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-02-25
- DOI
- https://doi.org/10.3389/fonc.2026.1767269
- Primary Topic
- Meningioma and schwannoma management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Technische Universität München