Multi-Omics Characterization of Lactate-Associated Molecular Subtypes in Lung Cancer Suggests a Role for DKK1 in Lactate-Linked Migration, Invasion, and Lactylation Programs
This study characterizes lactate-associated molecular heterogeneity in lung cancer and provides a lactate-related subtype framework and prognostic risk model for patient stratification. The findings nominate DKK1 as a lactate-responsive candidate linked to migration/invasion phenotypes and lactate/lactylation changes in vitro.
Authors
- Qing-Sui Li
- Junnan Guo (ORCID: https://orcid.org/0000-0002-6386-0660)
- Yang Dp
- Su Xu (ORCID: https://orcid.org/0000-0002-3695-5605)
- Xinru Chen (ORCID: https://orcid.org/0000-0002-9093-1911)
- Xiaobin An
- Long-Kai Yang
- Ning Wang
- Chen-Hong Li
- Hang Yu
- Long Qin
- Zhen Zhang
Institutions
- Harbin Medical University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Cancers
- Published
- 2026-02-25
- DOI
- https://doi.org/10.3390/cancers18050735
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00