Antidiabetic Polyphenolic Compounds Including Two Unique Dimers Featuring a 6/6/7/6/5 Ring System from the Roots of <i>Sophora tonkinensis</i>
Two unique polyphenolic compounds featuring a 6/6/7/6/5 fused skeleton, sotodisoflavanones A and B (<b>1</b> and <b>2</b>), and two novel 2-arylbenzofuran dimers shandougenines C and D (<b>3</b> and <b>4</b>) were isolated from the roots of <i>Sophora tonkinensis</i>. Their structures were elucidated through spectroscopic analysis and quantum chemical calculations. Compounds <b>1</b> and <b>5</b>-<b>7</b> showed significant PTP1B inhibition (IC<sub>50</sub> = 2.70 ± 0.50, 0.88 ± 0.17, 2.70 ± 0.50, 1.90 ± 0.40 μM, respectively) and enhanced insulin sensitivity by promoting HepG2 cell glucose consumption.
Authors
- Jian‐Shuang Jiang (ORCID: https://orcid.org/0000-0002-5693-0237)
- Zhang Xq
- Xiaoyun Yan (ORCID: https://orcid.org/0000-0003-3545-2077)
- Pei‐Cheng Zhang (ORCID: https://orcid.org/0000-0002-0739-0019)
- Jin Li (ORCID: https://orcid.org/0000-0002-6131-456X)
- Jie Yang (ORCID: https://orcid.org/0000-0003-4801-7162)
- Xiang Yuan
- Ya-Nan Yang
- Fei Ye
- Zi-Ming Feng
- Rui Zhang
Institutions
- Guangxi Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Shanghai Institute of Materia Medica (CN)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1021/acs.jnatprod.5c01551
- Primary Topic
- Bioactive natural compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00