Multimodal neuroimaging of locus coeruleus-default mode network connectivity for predicting dexmedetomidine response in chronic insomnia disorder
Pre-treatment LC-DMN functional and network topology differences may underlie variable responses to dexmedetomidine PCSL in chronic insomnia. The multimodal imaging model effectively predicts treatment sensitivity and may guide personalized interventions.
Authors
- Y. Li
- Yongtao Tang (ORCID: https://orcid.org/0000-0001-9847-4527)
- Yonghong Zhou
- Zhouquan Wu
- Haifeng Shi
- Yongqiong Tao
Institutions
- Jinshan Hospital of Fudan University (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Changzhou No.2 People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2026-02-25
- DOI
- https://doi.org/10.3389/fpsyt.2026.1718790
- Primary Topic
- Sleep and related disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nanjing Medical University
- Natural Science Foundation of Xinjiang