Prospects for the application of multiplex immunophenotyping in the practice of forensic histological examination

The article highlights the relevance of developing innovative technologies for the purposes of forensic pathology, describes the possibilities of the multiplex IHC method and shows some areas of its application. The tasks and problems of determining the vitality and age of injuries have been identified, which can be solved by using a multiplex IHC. The prospects of this method are revealed, which consist in the ability to formulate original hypotheses and ideas about the mechanisms of reparative regeneration, determine informative criteria of the local tissue microenvironment for detecting pathological changes, and identify new criteria for the inflammatory-reparative process in order to narrow time intervals and increase the accuracy of determining the prescription of damage in various types of trauma.

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Publication Details

Journal
Forensic Medical Expertise
Published
2026-02-25
DOI
https://doi.org/10.17116/sudmed20266901116
Primary Topic
Autopsy Techniques and Outcomes
Type
article
Field-Weighted Citation Impact
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article

Prospects for the application of multiplex immunophenotyping in the practice of forensic histological examination

M.V. FEDULOVA, D. A. Atyakshin, O I Patsap, A.A. Gusarov et al.
Forensic Medical Expertise
Autopsy Techniques and Outcomes
article

Prospects for the application of multiplex immunophenotyping in the practice of forensic histological examination

M.V. FEDULOVA, D. A. Atyakshin, O I Patsap, A.A. Gusarov, A.A. Kostin, A.V. Alekhnovich
article en

Abstract

The article highlights the relevance of developing innovative technologies for the purposes of forensic pathology, describes the possibilities of the multiplex IHC method and shows some areas of its application. The tasks and problems of determining the vitality and age of injuries have been identified, which can be solved by using a multiplex IHC. The prospects of this method are revealed, which consist in the ability to formulate original hypotheses and ideas about the mechanisms of reparative regeneration, determine informative criteria of the local tissue microenvironment for detecting pathological changes, and identify new criteria for the inflammatory-reparative process in order to narrow time intervals and increase the accuracy of determining the prescription of damage in various types of trauma.

Forensic Medical ExpertiseVol. 69(1)
Peoples' Friendship University of Russia (RU), Federal State Budgetary Institution "Center for Expertise and Quality Control of Medical Care" (RU), Federal Center of Brain Research and Neurotechnologies
Industry, innovation and infrastructure
Openalex Percentile: Top 45%
Autopsy Techniques and Outcomes
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