Single-cell analysis reveals immune remodeling of monocytes, NK cells, T cell exhaustion, and Galectin-9–associated depletion of gamma delta and mucosal-associated invariant T cells in Long COVID with ME/CFS
Our results reveal extensive peripheral immune remodeling in LC-ME/CFS, distinct from idiopathic ME/CFS, and support a model of chronic immune activation and dysregulation. Our findings offer a cellular framework for understanding LC pathogenesis and point to potential biomarkers and therapeutic targets for intervention.
Authors
- Hussain Syed
- Shokrollah Elahi (ORCID: https://orcid.org/0000-0002-7215-2009)
- Najmeh Bozorgmehr
- Mohammed Osman (ORCID: https://orcid.org/0000-0003-3580-6074)
- Amirhossein Rahmati
- Shima Shahbaz
- Amal Abouda
Institutions
- University of Alberta (CA)
- Northern Alberta Institute of Technology (CA)
- University of Alberta Hospital (CA)
- Institute of Cancer Research (CA)
- Alberta Cancer Foundation (CA)
- Women and Children’s Health Research Institute (CA)
- Alberta Glycomics Centre (CA)
- Institute of Virology of the Slovak Academy of Sciences (SK)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-25
- DOI
- https://doi.org/10.3389/fimmu.2026.1745933
- Primary Topic
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00