Longitudinal change of lung microbiome in chronic obstructive pulmonary disease: a prospective cohort study
Clinical factors in COPD are associated with distinct temporal shifts in the airway microbiome of patients with COPD. Longitudinal profiling combined with NBMMs with time-interaction terms revealed subtle microbial shifts with potential clinical implications that were not evident in cross-sectional analyses. These findings underscore the potential utility of temporal microbiome signatures in stratifying COPD patients and guiding future therapeutic strategies.
Authors
- Minhong Kim
- Ju Hye Shin (ORCID: https://orcid.org/0000-0003-1830-6828)
- Kangjin Kim (ORCID: https://orcid.org/0000-0002-3966-3309)
- Sung Woo Moon (ORCID: https://orcid.org/0000-0001-9917-9802)
- Sungho Won
- Hana Yi
- Chaeeun Kang
- Ji Ye Jung
- Eun Young Kim
Institutions
- Gachon University (KR)
- Seoul National University (KR)
- Yonsei University (KR)
- Korea University (KR)
- Severance Hospital (KR)
- Konkuk University Medical Center (KR)
- Department of Public (IN)
- Yonsei University Health System (KR)
- Korea University (JP)
Publication Details
- Journal
- Respiratory Research
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1186/s12931-025-03471-8
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00