Novel <i>Pfk13</i> and <i>Pfubp1</i> genotypes in African <i>Plasmodium falciparum</i> isolates exhibiting reduced susceptibility to the antimalarials artemisinin and lumefantrine
In our studies of UK travelers returning from Africa with malaria, we have encountered a small number of cases where standard combination drugs have failed to completely clear the infection. In this study, we present new assessments of the effectiveness of the major drugs in use against such parasites and link these findings to the genetic profiles of the parasites causing each infection. We identify new genetic types in some of these patient samples that may provide new markers for monitoring malaria drug resistance in African communities.
Authors
- Ryan C. Henrici
- Debbie Nolder (ORCID: https://orcid.org/0000-0002-5637-7785)
- Julian Muwanguzi-Karugaba
- Emma Filtenborg Hocke (ORCID: https://orcid.org/0000-0002-0040-7041)
- Charlotte Berry (ORCID: https://orcid.org/0000-0001-8360-5707)
- Donelly A. van Schalkwyk (ORCID: https://orcid.org/0000-0002-7375-3439)
- Sophie Moss (ORCID: https://orcid.org/0000-0003-2843-9085)
- Nina Billows (ORCID: https://orcid.org/0000-0002-3786-6911)
- Sade Pratt
- T. J. H. Clark
- Susana Campino
- Samirah Mannan
- Peter L. Chiodini
- Lindsay Stewart
- Jody Phelan
- Claire Rogers
- Colin J. Sutherland
Institutions
- London School of Hygiene & Tropical Medicine (GB)
- Centre for Global Health Research (CA)
Publication Details
- Journal
- mBio
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1128/mbio.03676-25
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- London School of Hygiene and Tropical Medicine
- UK Research and Innovation
- University College London
- University of New South Wales
- Medicines for Malaria Venture
- Medical Research Council
- Engineering and Physical Sciences Research Council
- Biotechnology and Biological Sciences Research Council