Ischemia-free liver transplantation protects coagulation function via the HNF4α–coagulation factor axis: a post hoc analysis from the IFLT-DBD randomized controlled trial
Adopting IFLT significantly decreased intraoperative hemorrhage and blood product transfusion. IFLT facilitates the restoration of intraoperative coagulation homeostasis by preserving the HNF4α-mediated regulation of hepatic coagulation factor synthesis.
Authors
- Wei Xiong (ORCID: https://orcid.org/0000-0002-2532-2503)
- Minglong Chen (ORCID: https://orcid.org/0000-0002-9844-486X)
- Xiaoxiang Chen (ORCID: https://orcid.org/0000-0002-3345-8830)
- Yuqi Dong
- Anbin Hu
- Yuekun Shen
- Xiaoshun He
- Qiang Zhao
- Zhiyong Guo
- Tao Zhang
- Weiqiang Ju
- Dongping Wang
- Lu Yang
- Bing Yang
Institutions
- Sun Yat-sen University (CN)
- Key Laboratory of Guangdong Province (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1097/js9.0000000000004987
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00