Construction of C–S and C–Se Bonds via Deaminative Coupling of Primary Amines

Herein, we report a versatile and efficient transition-metal-free protocol for the deaminative functionalization of primary alkyl and aryl amines, enabling the construction of sulfides, selenides, alkynes, alkenes, and oxime esters. This method exhibits excellent functional-group tolerance, a broad substrate scope, and scalability to gram quantities, rendering it highly attractive for the practical synthesis of organosulfur and organoselenium compounds.