IgE-defined endotypes reveal distinct clinical profiles of prurigo nodularis compared with atopic dermatitis: a multicenter study in China
In Chinese adults, PN exhibits clinical heterogeneity with two distinct patterns: one characterized by variability in type 2 immunity-associated and atopic features, and the other by a substantial burden of specific sociodemographic and metabolic comorbidities. Serum IgE may serve as a practical marker for stratifying type 2 immunity and atopic variability in PN.
Authors
- Mengting Yin (ORCID: https://orcid.org/0000-0002-9379-6321)
- Xia Zhong Dou
- Simon Ling
- Yan Liao (ORCID: https://orcid.org/0009-0006-2575-3879)
- Haiyan Huang (ORCID: https://orcid.org/0009-0001-6180-6249)
- Lu Wei (ORCID: https://orcid.org/0009-0005-6403-6867)
- Ruimiao Wu
- Chaofeng Chen
- Jiaying Chen
Institutions
- Shantou University (CN)
- Shantou University Medical College (CN)
- Peking University Shenzhen Hospital (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Frontiers in Allergy
- Published
- 2026-02-25
- DOI
- https://doi.org/10.3389/falgy.2026.1769768
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00