A thermosensitive hydrogel encapsulating 2-DG alleviates periodontitis by inhibiting glycolysis and effector response of Th17 cells
Th17-cell differentiation exacerbates periodontitis progression, and glycolysis inhibition effectively modulates Th17-driven immunity. The localized 2-DG hydrogel delivery system presents a promising translational strategy for periodontitis management.
Authors
- Jiabao Xu (ORCID: https://orcid.org/0000-0001-9197-8052)
- Ying Yue (ORCID: https://orcid.org/0000-0001-7657-6020)
- Siyi Chen (ORCID: https://orcid.org/0000-0002-0153-6152)
- Changyu Chen (ORCID: https://orcid.org/0000-0001-8888-1161)
- Jiandi Wu (ORCID: https://orcid.org/0000-0002-8657-5475)
- Ruihua Zhao (ORCID: https://orcid.org/0009-0007-0526-4952)
- Jiayu Yan (ORCID: https://orcid.org/0009-0007-7865-0619)
- jiayao fu
- Jia Li
Institutions
- Tongji University (CN)
- Fudan University (CN)
- University of Würzburg (DE)
- Shanghai Stomatological Hospital (CN)
- Tongji Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-02-25
- DOI
- https://doi.org/10.3389/fphar.2026.1767931
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality