Molecular mechanisms underlying the ferroptosis-induced epileptiform activity in mouse cortical slices
Our findings establish a direct link between lipid peroxidation and Xc<sup>-</sup> activity. These results suggest that the xCT antiporter may represent a promising therapeutic target for treating ferroptosis-mediated drug-resistant epilepsy.
Authors
- Fiorella Piemonte (ORCID: https://orcid.org/0000-0003-1825-9347)
- Sara Cairoli (ORCID: https://orcid.org/0000-0002-5925-0974)
- Federico Vigevano (ORCID: https://orcid.org/0000-0001-7513-0051)
- Enrico Cherubini (ORCID: https://orcid.org/0000-0002-1183-2772)
- Michela Giustizieri
- Bianca Maria Goffredo (ORCID: https://orcid.org/0000-0001-9933-3240)
- Sara Petrillo (ORCID: https://orcid.org/0000-0001-7891-760X)
- Caterina Torda
- Nicola Specchio
- Marina Trivisano
- Federica Loia
Institutions
- Vita-Salute San Raffaele University (IT)
- Bambino Gesù Children's Hospital (IT)
- IRCCS Ospedale San Raffaele (IT)
- European Brain Research Institute (IT)
- Epilepsy Foundation (AU)
Publication Details
- Journal
- Frontiers in Cellular Neuroscience
- Published
- 2026-02-25
- DOI
- https://doi.org/10.3389/fncel.2026.1758230
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ospedale Pediatrico Bambino Gesù
- Ministero della Salute