Alleviation of experimental arthritis in SKG mice through Nr4a1 agonization
Altogether, the findings of this study showed that CsnB, one of the agonists of <i>Nr4a1</i>, suppressed TCR-driven T cell activation and Th17 differentiation, thereby ameliorating autoimmune arthritis in SKG mice. These findings highlight the potential of <i>Nr4a1</i> as an immunotherapeutic target in T cell-mediated autoimmune arthritis, particularly in RA subsets characterized by TCR signaling dysfunction.
Authors
- Koji Kitagori (ORCID: https://orcid.org/0000-0001-8056-8648)
- Shuji Akizuki
- Hideaki Tsuji (ORCID: https://orcid.org/0000-0002-2521-246X)
- Mikihito Shoji
- A. Morinobu
- Hajime Yoshifuji (ORCID: https://orcid.org/0000-0001-7082-4900)
- Ryosuke Hiwa (ORCID: https://orcid.org/0000-0001-6968-5712)
- Ran Nakashima (ORCID: https://orcid.org/0000-0001-6247-0647)
- Y. Nakayama
- Mirei Shirakashi (ORCID: https://orcid.org/0000-0003-1135-0463)
- Ayaka Okubo
Institutions
- Kyoto University (JP)
- Social Welfare Department (HK)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-25
- DOI
- https://doi.org/10.3389/fimmu.2026.1758616
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company
- Japan Agency for Medical Research and Development
- University of California, San Francisco
- Eli Lilly Japan
- Japan Society for the Promotion of Science