Identification of core genes and transcription factors related to metabolic reprogramming in atherosclerosis: a multi-omics analysis and experimental validation approach
This study identifies LYN, FABP5, MMP9, and ANPEP as core MR-related genes in AS, clarifies their roles in immune microenvironment regulation, and confirms their value as diagnostic biomarkers, thereby providing new insights for precise diagnosis and targeted therapy of AS.
Authors
- Yirong Ma (ORCID: https://orcid.org/0009-0005-8180-184X)
- Jinhong Wu (ORCID: https://orcid.org/0000-0001-5754-1498)
- Zengguang Fan
- Junyu Lai (ORCID: https://orcid.org/0000-0002-8325-8765)
- Yuyu Liu (ORCID: https://orcid.org/0000-0002-4814-8616)
- Doukun Ding
- Zhijian Song
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2026-02-25
- DOI
- https://doi.org/10.3389/fmolb.2026.1756851
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00