A translational colorectal cancer organoid biobank mirrors patients’ tumor histology, molecular profiles, and treatment responses
This study establishes orthotopic transplantation of CRC PDOs as a robust and predictive preclinical model that captures the full spectrum of CRC heterogeneity. The model preserves histological and molecular subtype fidelity across in vitro and in vivo contexts and enables functional assessment of therapy response. By bridging patient-derived tumor biology with translational modeling, this platform provides a valuable resource for dissecting CRC pathogenesis and advancing patient-tailored precision oncology.
Authors
- Niklas de Andrade Krätzig (ORCID: https://orcid.org/0000-0003-2141-6745)
- Rupert Öllinger (ORCID: https://orcid.org/0000-0002-2292-5982)
- Julius Shakhtour
- M Tschurtschenthaler
- Nicole Pfarr (ORCID: https://orcid.org/0000-0002-5977-5375)
- Antonio Enrico Zaurito (ORCID: https://orcid.org/0000-0002-5657-1983)
- Peter Klare
- Valentina Brunner
- Sebastian Foersch (ORCID: https://orcid.org/0000-0002-4740-6900)
- Anantharamanan Rajamani (ORCID: https://orcid.org/0000-0001-9439-612X)
- Rad Roland (ORCID: https://orcid.org/0000-0002-6849-9659)
- Dieter Saur (ORCID: https://orcid.org/0000-0001-5874-0210)
- Federico Fusco
- Maxime Schmitt
- Nicholas Bodenstein
- Moritz Jesinghaus
- Junika Pohl
- Frederic Saab
- Rémi Guillemant
- Katja Steiger
- Miguel Gomes Silva
Institutions
- Philipps University of Marburg (DE)
- German Cancer Research Center (DE)
- Johannes Gutenberg University Mainz (DE)
- Heidelberg University (DE)
- Universitätsklinikum Gießen und Marburg (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- Technical University of Munich (DE)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1186/s13046-026-03666-x
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00