MRI based unsuperviced clustering on MIBC reveals intratumor heterogeneity phenotypes and neoadjuvant chemotherapy efficacy
The MRI-based IITH framework effectively stratified MIBC patients by prognosis and treatment response, with high heterogeneity being associated with adverse outcomes and aggressive molecular tumor biology.
Authors
- G F Wang
- Qiang Shao
- X Z Liu
- Xuping Jiang (ORCID: https://orcid.org/0000-0003-1484-838X)
- Yuhan Chen (ORCID: https://orcid.org/0000-0003-3674-1516)
- Lingkai Cai (ORCID: https://orcid.org/0000-0002-1056-9116)
- Rongjie Bai
- Hao Yu (ORCID: https://orcid.org/0000-0003-3343-158X)
- Chenghao Wang (ORCID: https://orcid.org/0000-0003-0641-6405)
- Meihua Jiang
- Z M Tan
- Qiang Cao
- Xiao Yang
- Qiang Lu
- Hao Yu
- Bo Liang
- Chang Chen
Institutions
- Jiangsu University (CN)
- Union Hospital (HK)
- Huaian First People’s Hospital (CN)
- Suzhou Municipal Hospital (CN)
- Yixing Tumor Hospital (CN)
- Yixing People's Hospital (CN)
- Jiangsu Province Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Wuxi People's Hospital (CN)
- Jiangsu Provincial Hospital of Traditional Chinese Medicine (CN)
- Huazhong University of Science and Technology (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Cancer Imaging
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1186/s40644-026-01007-x
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00