Metabolic, enterohepatic and gut microbial effects of atorvastatin in healthy men
This randomised, placebo-controlled, double-blind, crossover study reveals that short-term high-dose atorvastatin treatment increases fasting and postprandial glucagon levels and alters amino acid and bile acid profiles without affecting glucose, insulin, or gut microbiota in healthy men. These findings suggest hyperglucagonaemia as a potential mechanistic contributor to the increased risk of type 2 diabetes associated with statin therapy.
Authors
- Bart Staels (ORCID: https://orcid.org/0000-0002-3784-1503)
- Jonatan Kornholt (ORCID: https://orcid.org/0000-0003-2662-4519)
- Maria-Anna Misiakou (ORCID: https://orcid.org/0000-0002-9965-4164)
- Mari Cristina Rodriguez de Evgrafov (ORCID: https://orcid.org/0000-0002-8308-948X)
- Martin L. Kårhus (ORCID: https://orcid.org/0000-0002-3842-1287)
- Simone S. Li (ORCID: https://orcid.org/0000-0002-0073-3656)
- Andreas Brønden (ORCID: https://orcid.org/0000-0003-1262-3769)
- Amandine Descat (ORCID: https://orcid.org/0000-0002-5981-4995)
- TINA VILSBØLL
- Oscar Chavez-Talavera
- Nicolai J. Wewer Albrechtsen (ORCID: https://orcid.org/0000-0003-4230-5753)
- Martin Thomasen
- David P. Sonne (ORCID: https://orcid.org/0000-0002-4898-2256)
- Mads Bank Lynggaard (ORCID: https://orcid.org/0000-0002-5663-0234)
- Filip K. Knop (ORCID: https://orcid.org/0000-0002-2495-5034)
- Anne Tailleux (ORCID: https://orcid.org/0000-0003-1430-2627)
- Anne‐Marie Ellegaard (ORCID: https://orcid.org/0000-0002-4389-3908)
- Morten O A Sommer
- Bolette Hartmann
- Jens F Rehfeld
- Jens J Holst
Institutions
- University of Copenhagen (DK)
- Steno Diabetes Centers (DK)
- Inserm (FR)
- Institut Pasteur de Lille (FR)
- Novo Nordisk Foundation (DK)
- Frederiksberg Hospital (DK)
- Australian Regenerative Medicine Institute (AU)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- Rigshospitalet (DK)
- Centre Hospitalier Universitaire de Lille (FR)
- Monash University (AU)
- Technical University of Denmark (DK)
Publication Details
- Journal
- Endocrine Connections
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1530/ec-25-0721
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Augustinus Fonden