Mapping the degenerating intervertebral disc: a systematic review of histological evidence
Histology reveals spatially distinct yet converging degenerative pathways across IVD regions. These findings identify potential biomarkers and therapeutic targets, supporting histological analysis as an essential complement to imaging for accurate IDD characterization.
Authors
- Gianluca Giavaresi (ORCID: https://orcid.org/0000-0001-7843-5969)
- Francesca Veronesi (ORCID: https://orcid.org/0000-0002-6750-9376)
- F. Rosa (ORCID: https://orcid.org/0009-0000-9570-5289)
- Giuseppe Tedesco
- Francesca Salamanna
- Cesare Faldini
- Alberto Ruffilli
Institutions
- Istituto Ortopedico Rizzoli (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-02-25
- DOI
- https://doi.org/10.3389/fmed.2026.1753988
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00