Notopterol attenuates atherosclerosis by promoting macrophage cholesterol efflux via targeting KEAP1/NRF2 interaction
• NOT reduces atherosclerotic plaque in apoE - / - mice: decreases lipid accumulation and lesion area, improves plasma lipids. • NOT enhances cholesterol efflux in macrophages: boosts ABCA1/G1 expression and efflux, reducing cholesterol in foam cells. • Nrf2-HO-1 pathway mediates NOT effects: involved in ABCA1/G1 expression and atherosclerosis protection. • NOT disrupts Keap1-Nrf2 complex: binds Keap1, inhibits complex formation, activating Nrf2-HO-1 pathway. • Study offers new insights: NOT's atherosclerotic protection suggests therapeutic potential for prevention.
Authors
- Jun Meng (ORCID: https://orcid.org/0000-0002-7357-8562)
- Juan Yi (ORCID: https://orcid.org/0009-0000-2180-0590)
- Wei Zhang
- Yusheng Qin
- Yanjun Chen
- Shuzhi Wang
Institutions
- Army Medical University (CN)
- Liuzhou Maternal and Child Health Hospital (CN)
- Liuzhou General Hospital (CN)
- Southwest Hospital (CN)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of University of South China (CN)
- University of South China (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1016/j.intimp.2026.116404
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00