Peripheral blood inflammatory ratios predict efficacy and toxicity of CAR-T cell immunotherapy in relapsed/refractory multiple myeloma
Baseline peripheral blood inflammatory ratios are closely associated with CAR-T cell efficacy and CRS severity in R/R MM patients receiving CAR-T therapy. The CIPI score represents a simple and reproducible prognostic biomarker that may help individualized risk stratification and inform treatment optimization in CAR-T therapy.
Authors
- Qing-Yun Wu
- C. Chen
- Jiang Cao
- Huan-Xin Zhang (ORCID: https://orcid.org/0000-0002-2312-3762)
- Can Huang
- Yao Liu (ORCID: https://orcid.org/0000-0002-0700-0148)
- Z L Yan
- Yang Liu
- Wei Dai
- Ke Ji
- Peng Xu
Institutions
- Xuzhou Medical College (CN)
- Affiliated Hospital of Xuzhou Medical College (CN)
- Suzhou Municipal Hospital (CN)
- Stem Cell Institute (PA)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-25
- DOI
- https://doi.org/10.3389/fimmu.2026.1752235
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Xuzhou Medical University