Magnetic resonance spectroscopy as a non-invasive tool for assessing brain and muscle adaptation to exercise training in older age: a scoping review into existing research
Despite limited guidance on methods and biomarkers, this scoping review supports MRS as a promising tool for monitoring exercise-induced metabolic changes in muscle and brain of older adults. However, standardized methodologies and larger number of studies are required to determine which metabolites reliably reflect exercise benefits in aging brain and muscle.
Authors
- Michel Francis Audiffren (ORCID: https://orcid.org/0000-0002-2488-8089)
- Martin Krššák (ORCID: https://orcid.org/0000-0001-9717-803X)
- Claudia Voelcker‐Rehage (ORCID: https://orcid.org/0000-0001-5398-4099)
- Ivica Just
- Christina Karatzaferi (ORCID: https://orcid.org/0000-0002-8266-5780)
- Yaël Netz (ORCID: https://orcid.org/0000-0001-6554-0102)
- Wouter A. J. Vints (ORCID: https://orcid.org/0000-0003-1803-4949)
- Radka Klepochová (ORCID: https://orcid.org/0000-0001-8268-5258)
- Maryam Ziaei (ORCID: https://orcid.org/0000-0003-2758-8038)
- Nerijus Masiulis (ORCID: https://orcid.org/0000-0002-2137-4226)
- Ana Filipa Silva (ORCID: https://orcid.org/0000-0001-5470-9523)
- Uwe Himmelreich
- Salit Bar Shalom
- Oron Levin
- Shannon Helsper
- Antoine Langeard
Institutions
- Centre National de la Recherche Scientifique (FR)
- Lithuanian Sports University (LT)
- University of Thessaly (GR)
- Inserm (FR)
- Norwegian University of Science and Technology (NO)
- University of Münster (DE)
- Polytechnic Institute of Coimbra (PT)
- Academic College at Wingate (IL)
- Centre de Recherches sur la Cognition et l'Apprentissage (FR)
- Department of Health (TW)
- Maison des Sciences sociales et des Humanités Ange Guépin (FR)
- Medical University of Vienna (AT)
- Université de Caen Normandie (FR)
- KU Leuven (BE)
Publication Details
- Journal
- Experimental Gerontology
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1016/j.exger.2026.113082
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00