Concordance Analysis of Microsatellite Instability via NGS and Mismatch Repair Deficiency via IHC in Endometrial and Colorectal Cancer
These findings confirm the lower concordance between MMR-IHC and MSI-NGS in endometrial cancer compared with colorectal cancer when broad panels are used, underscoring the importance of tumor-specific interpretation even within tumor-agnostic assays. Although cut-off optimization improved agreement, the evidence remains insufficient for clinical implementation, and further validation studies are needed.
Authors
- Simona Duranti (ORCID: https://orcid.org/0000-0002-1924-238X)
- Maria Alessandra Calegari (ORCID: https://orcid.org/0000-0001-6856-2593)
- Luciano Giacò (ORCID: https://orcid.org/0000-0003-0657-4323)
- Giulia Caira
- Valentina Iacobelli (ORCID: https://orcid.org/0000-0002-5874-3320)
- Gloria Anderson (ORCID: https://orcid.org/0000-0003-2929-9328)
- Giulia Mantini
- Luca Mastrantoni (ORCID: https://orcid.org/0000-0003-1853-4927)
- Arianna Panfili (ORCID: https://orcid.org/0009-0007-4701-7845)
- G. Trovato (ORCID: https://orcid.org/0009-0004-9526-0725)
- Giulia Maneri (ORCID: https://orcid.org/0000-0002-6455-8973)
- A. Minucci
- Mina Karimi
- Giampaolo Tortora
- Alessia Piermattei (ORCID: https://orcid.org/0000-0001-7164-4952)
- Lisa Salvatore
- Camilla Nero
- Angela Santoro
- Giovanni Scambia
- Francesco Fanfani
- Vanda Salutari
- Nicola Normanno
- Ilenia Marino
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Agostino Gemelli University Polyclinic (IT)
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
Publication Details
- Journal
- Targeted Oncology
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1007/s11523-026-01197-1
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00