Danggui Shaoyao San ameliorates neuroinflammation in a D-galactose-induced Alzheimer’s disease rat model by suppressing the JAK2/STAT3 pathway and modulating Th17/Treg -related immune dysregulation
DSS is a promising candidate for AD treatment, with neuroprotective and cognitive-enhancing properties mediated through immunomodulation and JAK2/STAT3 pathway inhibition.
Authors
- Pan Meng
- Song Zhenyan
- Xin Sun (ORCID: https://orcid.org/0000-0002-5131-0012)
- Mengfen Zhou
- Gangying Fu
- Jiajun Tong
- Ping Li
- Shuyao Tang
- Shaowu Cheng
Institutions
- Hunan University of Traditional Chinese Medicine (CN)
- Integrated Chinese Medicine (China) (HK)
- Hunan Academy of Traditional Chinese Medicine (CN)
- Ministry of Education (TH)
- China Academy of Chinese Medical Sciences (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-02-25
- DOI
- https://doi.org/10.3389/fcell.2026.1763180
- Primary Topic
- Antioxidants, Aging, Portulaca oleracea
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province