Palladium-Catalyzed Enantioselective Tandem Allylation/Cyclization of <i>ortho</i> -Alkynylbenzaldehydes with Allyltrimethylsilane: Access to Chiral 1-Allyl-1 <i>H</i> -isochromenes
Herein, we report the first palladium-catalyzed asymmetric Sakurai-Hosomi-type tandem allylation/cyclization of <i>ortho</i>-alkynylbenzaldehydes with allyltrimethylsilane. A chiral Pd(II)/<b>L11</b> complex combined with ZnCl<sub>2</sub> and Cu(OAc)<sub>2</sub> afforded 1-allyl-1<i>H</i>-isochromenes (22 examples) in up to 82% yield and 97% ee. This protocol provides a concise, efficient, and practical route to chiral isochromene scaffolds of biological significance.
Authors
- Ruifeng Fan
- Zhenxiu He
- Ponnam Devendar (ORCID: https://orcid.org/0000-0003-3079-1491)
- linchun Zhang
- Meiqi Liang
- M. Wang
- Baomin Fan
Institutions
- Minzu University of China (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1021/acs.orglett.6c00112
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00