Case Report: A novel use of Transcranial Pulse Stimulation in refractory Restless Legs Syndrome

In this single case, TPS was well tolerated and associated with meaningful symptomatic improvement. While no conclusions regarding safety or efficacy can be drawn from an individual observation, these findings suggest that TPS may warrant further investigation as non-invasive neuromodulatory approach for refractory RLS. This report expands the scientific literature by introducing a novel network-based neuromodulation modality to the RLS field and provides a foundation for future controlled studies to validate efficacy and optimize stimulation protocols.