Elevated circulating GDF11 and its role in age-related sarcopenia: insights from clinical, transcriptomic, and in vitro analyses
Circulating GDF11 is elevated in individuals with sarcopenia and appears to partially mediate the protective effects of physical activity. Together with functional evidence of activation of catabolic signaling pathways, these findings support a contributory role of circulating GDF11 in age-related muscle loss.
Authors
- Hao Wang (ORCID: https://orcid.org/0000-0001-6881-9977)
- Yaoxia Liu
- Zhao Zhang
- Ting Zhang
- Zhen Fan
- Rui Chen
- Xin Dai
Institutions
- University of Electronic Science and Technology of China (CN)
Publication Details
- Journal
- Frontiers in Aging
- Published
- 2026-02-25
- DOI
- https://doi.org/10.3389/fragi.2026.1736069
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China