Integrated analysis and validation of metabolism-related genes in lung transplantation-induced cold ischemia/ reperfusion injury

We identified multiple metabolism-related genes machine learning genes (<i>PDE4B</i>, <i>CDA</i>, <i>HMOX1</i>, <i>EHHADH</i>, <i>AMD1</i>, <i>GUCY1A1</i>, <i>GUCY1B1</i>, <i>UGCG</i>, and <i>FPGT</i>). Significant changes were observed in some of these genes following ischemia-reperfusion. They represent important biomarkers in ischemia-reperfusion injury induced by lung transplantation and hold promise as therapeutic targets for mitigating lung ischemia-reperfusion injury and reducing the incidence of primary graft dysfunction.