Early rise in nasal secretory IgA associated with shorter duration of SARS-CoV-2 virus shedding in an acute infection cohort
These findings demonstrate that early rises in serum and mucosal IgA titers are associated with reduced duration of viral shedding. Notably, nasal secretory IgA responses targeting the spike N-terminal domain were most strongly associated with shorter shedding, suggesting a potentially protective role for SARS-CoV-2-specific nasal IgA during acute SARS-CoV-2 infection. These results highlight the importance of mucosal immunity for limiting viral transmission and shedding, offering future insights for pan-coronavirus therapeutics and vaccine development aimed for enhancing SARS-COV-2 mucosal antibody responses.
Authors
- Olivier Hyrien (ORCID: https://orcid.org/0000-0001-8879-675X)
- Saman Baral
- Caroline Brackett (ORCID: https://orcid.org/0000-0001-9371-6144)
- Fisher Ld
- Shuying S. Li (ORCID: https://orcid.org/0000-0001-9045-699X)
- Alexander J Carnacchi
- Bich Thuy Thi N
- Kelly Seaton
- A L Greninger
- William O. Hahn
- Lakshmanane Premkumar
- Sir’Tauria Hilliard
- Lu Zhang
- Georgia D. Tomaras
Institutions
- University of North Carolina at Chapel Hill (US)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- Duke University (US)
- University of Washington Medical Center (US)
- Fred Hutch Cancer Center (US)
- Cancer Research Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-25
- DOI
- https://doi.org/10.3389/fimmu.2026.1722585
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bill and Melinda Gates Foundation
- Fred Hutchinson Cancer Research Center
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases