Development of a Flow Process to <i>tert</i> -Butyl 4-(6-Chloropyridin-2-yl)piperidine-1-carboxylate
This paper outlines the development of a continuous manufacturing process for producing the key compound tert-butyl 4-(6-chloropyridin-2-yl)piperidine-1-carboxylate. A 3-step process, performed in batch, had been utilized to deliver significant quantities of the target compound. By employing the same bond-forming chemistry, we designed, optimized, and scaled a flow process that delivers multikilogram quantities of tert-butyl 4-(6-chloropyridin-2-yl)piperidine-1-carboxylate with equivalent quality. This new process offers several superior metrics, including lower PMI and reduced cycle time.
Authors
- Philip Peach
- Angela L. A. Puchlopek-Dermenci
- Taegyo Lee (ORCID: https://orcid.org/0000-0001-7847-8264)
- Aaron F. Baldwin (ORCID: https://orcid.org/0000-0002-5621-0555)
- Craig J. Knight
- David F. Fernández (ORCID: https://orcid.org/0000-0003-3482-0894)
- Long Yuan (ORCID: https://orcid.org/0000-0003-1863-2308)
- Nga M.
- Rachel Ruest
- Steven J. R. Twiddle
- Guodu Zhang
- Xican He
- Bin Liu
- Mark Duane McLaws
Institutions
- Pfizer (United States) (US)
- Pfizer (United Kingdom) (GB)
- Tianjin Economic-Technological Development Area (CN)
Publication Details
- Journal
- Organic Process Research & Development
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1021/acs.oprd.5c00467
- Primary Topic
- Innovative Microfluidic and Catalytic Techniques Innovation
- Type
- article
- Field-Weighted Citation Impact
- 0.00