Impact of SGLT2 Inhibitors on Kidney Function Among People with HIV: A US Prospective Multi-Site Study

Acute eGFR dips were more common among PWH initiating SGLT2i relative to other antihyperglycemic classes, though overall declines were small, transient, and consistent with the general population. Further research is needed to explore the long-term effects of SGLT2i in PWH.

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Publication Details

Journal
JAIDS Journal of Acquired Immune Deficiency Syndromes
Published
2026-02-24
DOI
https://doi.org/10.1097/qai.0000000000003854
Primary Topic
Diabetes Treatment and Management
Type
article
Field-Weighted Citation Impact
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article

Impact of SGLT2 Inhibitors on Kidney Function Among People with HIV: A US Prospective Multi-Site Study

Christine Leong, Laila Aboulatta, Carolyn Fahey, Alexander Commanday et al.
JAIDS Journal of Acquired Immune Deficiency Syndromes
Diabetes Treatment and Management
article

Impact of SGLT2 Inhibitors on Kidney Function Among People with HIV: A US Prospective Multi-Site Study

Christine Leong, Laila Aboulatta, Carolyn Fahey, Alexander Commanday, M. S. Saag, Ryan Kyle, S. S. Heath, Stephanie A. Ruderman, Lara Haidar, K. Mayer, Malcolm Bray Doupe, J A C Delaney, Greer Burkholder, Sherif Eltonsy, Sonia Napravnik, April C Pettit, Richard D Moore, Katerina Christopoulos, Mari M Kitahata, Heidi M Crane, Robert Kalayjian, Laura Bamford
article en

Abstract

Acute eGFR dips were more common among PWH initiating SGLT2i relative to other antihyperglycemic classes, though overall declines were small, transient, and consistent with the general population. Further research is needed to explore the long-term effects of SGLT2i in PWH.

JAIDS Journal of Acquired Immune Deficiency Syndromes
University of North Carolina at Chapel Hill (US), Johns Hopkins University (US), University of California, San Francisco (US), Vanderbilt University (US), University of Washington (US), University of Alabama at Birmingham (US), Alstom (France) (FR), University of California San Diego (US), Mayo Clinic in Arizona (US), Fenway Health (US), University of Manitoba (CA), Case Western Reserve University (US)
Good health and well-being
Openalex Percentile: Top 46%
Diabetes Treatment and Management
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