SIGNIFIED: whole-body MRI screening in Li–Fraumeni syndrome in the UK
WB-MRI can identify early cancers in the high-risk setting of LFS screening, with cancers detected at both baseline and 12-month follow-up screenings. The burden of additional investigations for incidental findings decreases with repeat imaging.
Authors
- E. Scurr
- R. Eeles
- C.S. Clarke
- A. George
- C. Bunce
- R.W. Lee
- S.J. Withey
- J.Y. Weng
- E. Finn
- A. Sohaib
- S. Sardo Infirri
Institutions
- Royal Marsden NHS Foundation Trust (GB)
- London School of Hygiene & Tropical Medicine (GB)
- Lung Institute (US)
- University College London (GB)
Publication Details
- Journal
- ESMO Open
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1016/j.esmoop.2025.106045
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Royal Marsden NHS Foundation Trust
- National Institute for Health and Care Research
- Samsung Biomedical Research Institute