MiR-34a deficiency enhances nucleic acid sensing and type I IFN signaling in a mouse model of Alzheimer’s disease
Our results suggest that miR-34a inhibits the transition of microglia to the IRM state that may modulate synaptic and cognitive functions in neurodegenerative diseases and aging.
Authors
- Mark Maienschein‐Cline
- Robert Lalonde (ORCID: https://orcid.org/0000-0003-4176-3525)
- George E. Tsourdinis
- Jie Yang (ORCID: https://orcid.org/0000-0003-4801-7162)
- Charlotte Holas
- Ken-ichiro Fukuchi
Institutions
- Illinois College (US)
- Chicago Department of Public Health (US)
- University of Illinois Chicago (US)
- Peoria campus of the University of Illinois System (US)
- Illinois CancerCare (US)
- Stress, immunité, pathogènes
- Université de Lorraine (FR)
- Core Laboratories (United States) (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-24
- DOI
- https://doi.org/10.3389/fimmu.2026.1694824
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00