Parental obesity and risk of metabolic dysfunction associated steatotic liver disease in adult offspring: UK birth cohort study
Excess parental adiposity pre-pregnancy was associated with a higher odds of offspring MASLD, mediated by cumulative excess childhood BMI, highlighting the potential of life course interventions to reduce the risk of MASLD in future generations.
Authors
- Stefani Tica (ORCID: https://orcid.org/0000-0002-6935-9746)
- Chongliang Luo (ORCID: https://orcid.org/0000-0003-3682-9454)
- Michael D. Thompson (ORCID: https://orcid.org/0000-0003-3858-7516)
- Duo Ren
- Yin Cao (ORCID: https://orcid.org/0000-0002-4821-3879)
- Tarr Phillip
- Xiaoyu Zong
- Brian Jesse DeBosch
- Janis Stoll
Institutions
- Washington University in St. Louis (US)
- Jewish Hospital (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Gut
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1136/gutjnl-2025-336165
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 63.04