Dual-probe genome mining identifies citrulassin N, a novel citrulline modified lasso peptide from Streptomyces sp. NAX00255
This study expands the structural diversity of citrulline-containing lasso peptides, demonstrates the utility of a dual-probe genome-mining approach for identifying RiPPs with rare post-translational modifications, and provides a practical framework for the targeted discovery of functionally decorated RiPP natural products.
Authors
- Zhangyuan Yan (ORCID: https://orcid.org/0000-0002-9094-363X)
- Chao Zeng (ORCID: https://orcid.org/0000-0002-4147-0178)
- Dan Feng
- Zi-Fei Xu
Institutions
- Jiangsu University (CN)
- Kunming Institute of Botany (CN)
- Chinese Academy of Sciences (CN)
- Affiliated Hospital of Jiangsu University (CN)
- Laboratoire des Biomolécules (FR)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-02-24
- DOI
- https://doi.org/10.3389/fmicb.2026.1786444
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Natural Science Foundation of Yunnan Province