Exploring neural correlates of automated speech-based cognitive markers through resting-state functional connectivity in aging and at-risk Alzheimer’s disease

Digital speech-based assessments may have limited current utility for detecting FC alterations in at-risk individuals. Further validation using complementary methodological approaches, shorter intervals between fMRI and speech assessments, and testing in independent cohorts, are essential to establish their reliability and clinical relevance for monitoring brain network changes.

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Publication Details

Journal
Alzheimer s Research & Therapy
Published
2026-02-24
DOI
https://doi.org/10.1186/s13195-026-01993-x
Primary Topic
Functional Brain Connectivity Studies
Type
article
Field-Weighted Citation Impact
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article

Exploring neural correlates of automated speech-based cognitive markers through resting-state functional connectivity in aging and at-risk Alzheimer’s disease

Antje Osterrath, Claudia Bartels, Franziska Maier, Zampeta-Sofia Alexopoulou et al.
Alzheimer s Research & Therapy
Functional Brain Connectivity Studies
article

Exploring neural correlates of automated speech-based cognitive markers through resting-state functional connectivity in aging and at-risk Alzheimer’s disease

Antje Osterrath, Claudia Bartels, Franziska Maier, Zampeta-Sofia Alexopoulou, Qingyue Li, Elisa Mallick, Björn Falkenburger, J Wiltfang, Michaela Butryn, Sebastian Sodenkamp, Stefanie Köhler, Emrah Duezel, Ingo Kilimann, Slawek Altenstein, Martin Dyrba, Eike Spruth, DESCRIBE study groups DELCODE, Michael Wagner, Annika Spottke, Anja Schneider, Josef Priller, Enise I. Incesoy, Wenzel Glanz, Frank Jessen, Johannes Tröger, Christoph Laske, Gabor C. Petzold, Stefan Teipel, Alexandra König
article en

Abstract

Digital speech-based assessments may have limited current utility for detecting FC alterations in at-risk individuals. Further validation using complementary methodological approaches, shorter intervals between fMRI and speech assessments, and testing in independent cohorts, are essential to establish their reliability and clinical relevance for monitoring brain network changes.

Alzheimer s Research & TherapyVol. 18(1)
University of Cologne (DE), University Hospital Bonn (DE), German Center for Neurodegenerative Diseases (DE), Centre Hospitalier Universitaire de Nice (FR), Universitätsmedizin Göttingen (DE), UK Dementia Research Institute (GB), Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE), Cognition Behaviour Technology (FR), Klinikum Saarbrücken (DE), University Hospital Carl Gustav Carus (DE), University of Rostock (DE), University of Aveiro (PT), Technical University of Munich (DE), University of Göttingen (DE), Charité - Universitätsmedizin Berlin (DE), University of Tübingen (DE), University of Edinburgh (GB)
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Functional Brain Connectivity Studies
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