Cyclover-Assisted Liquid-Phase Peptide Synthesis Using T3P® as a Green Coupling Reagent
Liquid-phase peptide synthesis (LPPS) continues to evolve toward more sustainable and efficient methodologies. In this study, we introduce Cyclover as a tag that enables efficient, tunable LPPS in 2Me-THF using propylphosphonic anhydride (T3P®) as a coupling reagent. The extraction protocol reduces the PMI ∼2.7-fold while maintaining high purity and isolated yield, offering a greener and versatile route to complex peptides.
Authors
- Marvin Mantel (ORCID: https://orcid.org/0000-0002-3541-3388)
- Peter Talbiersky
- Aparna Sharma (ORCID: https://orcid.org/0000-0002-7369-2007)
- Priyanka Kushwaha
- Fernando Albericio
- Beatriz G. de la Torre
- Yongfu Li
Institutions
- College of Medical Sciences (NP)
- Corvallis Environmental Center (US)
- Klinikum Frankfurt Höchst (DE)
- Universitat de Barcelona (ES)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1021/acs.orglett.6c00353
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00