Defining Discordance Between Signs and Symptoms in Dry Eye Disease: Insights From the DRy Eye Assessment and Management (DREAM) Study
Symptom-sign discordance in DED is common, multifactorial, and persists over time. This is the first study to apply and compare 3 discordance classification methods in a single cohort. Each offers distinct clinical utility, allowing clinicians to better stratify DED patients and enabling more targeted treatment and referral strategies, thus improving outcomes.
Authors
- Rony R. Sayegh (ORCID: https://orcid.org/0000-0002-0119-4201)
- Yinxi Yu (ORCID: https://orcid.org/0000-0003-3820-1257)
- Asbell PA
- Patrick Augello (ORCID: https://orcid.org/0009-0003-5897-3497)
- Karen Matar
- Gui-Shuang Ying
Institutions
- Penn Presbyterian Medical Center (US)
- Cleveland Eye Clinic (US)
- Temple University (US)
- University of Memphis (US)
Publication Details
- Journal
- American Journal of Ophthalmology
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1016/j.ajo.2026.02.031
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 0.00