Seizures as the initial manifestation: characterizing the adult phenotype of MOG antibody-associated disease

In adult MOG antibody-positive patients presenting with epileptic seizures as the initial symptom, the disease can occur at any age without a clear sex predominance. These patients may present with non-specific clinical features such as fever, headache, and abnormalities in cerebrospinal fluid and electroencephalography. Some patients may exhibit isolated epileptic seizures. Cranial magnetic resonance imaging often reveals cortical signal abnormalities. For adult patients presenting with seizures as the first symptom, early MOG antibody testing is essential for a definitive diagnosis. Prompt initiation of corticosteroid or intravenous immunoglobulin therapy can effectively control disease progression.