Molecular Signatures of Peripheral and Central Dental Pulp Subpopulations in Response to <scp> <i>Streptococcus mutans</i> </scp> : A Bulk <scp>RNA</scp> ‐Seq Analysis
Following exposure to S. mutans, mechanically isolated DACs and DPCs displayed distinct transcriptomic profiles, indicating functional heterogeneity in the pulpal immune response. DACs engaged immunomodulatory pathways, while DPCs were marked by cellular stress responses, suggesting divergent contributions to tissue defence and homeostasis.
Authors
- Wolfgang Buchalla (ORCID: https://orcid.org/0009-0006-7575-6947)
- M Huber
- Tobias Akamp
- Andreas Rosendahl
- Matthias Widbiller (ORCID: https://orcid.org/0000-0002-7917-9466)
- Sandra Pohl (ORCID: https://orcid.org/0000-0001-7409-7042)
- Lea Schreiber
- Nicholas Strieder (ORCID: https://orcid.org/0000-0003-1183-1099)
- Claudia Gebhard (ORCID: https://orcid.org/0000-0002-5459-8381)
- Michael Rehli
- Melanie Linnebank
Institutions
- University Hospital Regensburg (DE)
- Leibniz Institute for Immunotherapy
Publication Details
- Journal
- International Endodontic Journal
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1111/iej.70117
- Citations
- 1
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 42.00