Investigating Interleukin-19 and Interleukin-33 in Breast Cancer of Iraqi Women: An Immunohistochemical Study

Cytokines are immune elements that have been found as marker either for tumor-promoting or inhibiting effects on breast tumor development, depending evidently on their exact quantities as well as the existence of additional modifying variables. The study aims to evaluate the relationship between breast cancer tissue and the expression level of IL-19 and IL-33. This study includes using breast cancer tissue (30 specimens) and normal breast tissue (20 specimens) to analyze the expression level of IL-19 and IL-30. Using immunohistochemical technique, the results indicated that lL-33 and also IL-19 were strongly elevated in patients with stage II and stage III of BC, compared to stage I. Also, IL-33 and IL-19 were highly expressed in patients with grade II and grade III BC, compared to grade I. In cancer tissues, expression of IL-33 and IL-19 was higher than in normal breast tissues. These data imply that IL-33 and IL-19 may play a significant role in the progress of BC and may be helpful biomarkers to identify the progress and metastasis of BC.