Integrated multi-omics mapping of the causal landscape of gout across the circulating-tissue axis
This integrative analysis establishes a causal framework linking specific lipoprotein subfractions, amino acid metabolism, and novel effector genes to gout pathogenesis, elucidating the systemic metabolic architecture of the disease and identifying potential therapeutic candidates warranting further preclinical investigation before clinical translation.
Authors
- Xi Chen (ORCID: https://orcid.org/0000-0002-8523-3967)
- Siqi Zhang (ORCID: https://orcid.org/0000-0002-9815-4395)
- Meng Li (ORCID: https://orcid.org/0009-0007-6919-3858)
- Li Cai (ORCID: https://orcid.org/0000-0003-0491-6334)
- Shanshan Cai (ORCID: https://orcid.org/0000-0003-0117-5171)
- Liang Huang
- Yanyan Guo
- Peng Zhu
- Kai Zhang
- Xiaohui Zheng
- Jiani Liu
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Nanjing University of Chinese Medicine (CN)
- Nantong University (CN)
- Tangshan People's Hospital (CN)
- Nanfang Hospital (CN)
- Second Affiliated Hospital of Zhengzhou University (CN)
- Guangxi University of Chinese Medicine (CN)
- Taishan University (CN)
- The Affiliated Taizhou People's Hospital of Nanjing Medical University (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Southern Medical University (CN)
- Lancaster University (GB)
- University of South China (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-24
- DOI
- https://doi.org/10.3389/fimmu.2026.1776456
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 0.00