Controlled Release Matrix Tablets of Metformin HCl: Role of Xanthan Gum in Sustained Drug Release

The Aim of this present study was to develop an oral sustained release matrix tablet of metformin HCl and evaluate the influence of Xanthum gum on the drug release profile. The use of FTIR for drug – excipient compatibility is appropriate. The wet granulation method is suitable for matrix tablet preparation, incorporating hydrophilic HPMC K100M, PVP K30, and Xanthan gum as controlling agents for the release rate. Lactose served as the filler. The physicochemical tests (weight variation, hardness, friability, content uniformity, and in vitro dissolution) were standard and appropriately listed. Both pre- and post-compression parameters are good that both stages were evaluated in this study. The data on drug release were analyzed using multiple models to determine the kinetics and mechanism of drug release. A clear comparison between HPMC alone and HPMC – Xanthum gum combination was made. Quantify the difference in drug release, HPMC alone released 90% of drug within 6 hours, while the combination extended release to 12 hours. Release kinetics following Zero order kinetics with Higuchi model diffusion-controlled release mechanism. Formulation F8 was identified as the optimal formulation. The dissolution profile of formulation F8 can be characterized by Release kinetics following Zero order kinetics with Higuchi model diffusion-controlled release mechanism. Keywords: Matrix tablets, Metformin hydrochloride, Xantham gum, HPMCK100, PVPK30