Analysis of the rs3807135, rs3757385 and rs3778754 Variants of the IRF5 Gene and mRNA Expression in Patients with Melanoma Cancer from Western Mexico

In conclusion, the present study did not identify statistically significant associations between the <i>IRF5</i> single-nucleotide variants rs3807135, rs3757385, and rs3778754 and melanoma risk in the analyzed population from western Mexico. Likewise, no significant differences in allele or genotype distributions were observed between melanoma patients and control individuals. These findings suggest that the evaluated <i>IRF5</i> genetic variants do not constitute major susceptibility factors for melanoma in this cohort.